Pathogenicity of H5N8 avian influenza virus in chickens and in duck breeds and the role of MX1 and IFN-α in infection outcome and transmission to contact birds
A Nahed, WSH Abd El Naby, EGS Hussein… - … and Infectious Diseases, 2023 - Elsevier
This study examined the pathogenicity, immunogenicity, and transmission potential of the
H5N8 HPAI clade 2.3. 4.4 b virus in three breeds of ducks and in broiler chickens. Chickens,
Muscovy, Pekin, and Mallard ducks (n= 10) received a dose of 6 log 10 EID 50 of HPAIV
H5N8 directly. Nine contact chickens were introduced to each group on the day of infection.
All infected chickens died, with MDT of 7.6 days. Muscovy and Pekin ducks died by 11.1%
and 10%, respectively, with MDTs of 7 and 6 days. No Mallards died but showed more …
H5N8 HPAI clade 2.3. 4.4 b virus in three breeds of ducks and in broiler chickens. Chickens,
Muscovy, Pekin, and Mallard ducks (n= 10) received a dose of 6 log 10 EID 50 of HPAIV
H5N8 directly. Nine contact chickens were introduced to each group on the day of infection.
All infected chickens died, with MDT of 7.6 days. Muscovy and Pekin ducks died by 11.1%
and 10%, respectively, with MDTs of 7 and 6 days. No Mallards died but showed more …
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