… C) to treat patients with severe sepsis. Previously, it was believed that sepsis merely
represented an … More recent data indicate that substantial heterogeneity exists in septic patients' …

The roles of inflammation and coagulation in the pathophysiology of sepsis are described.
Sepsis results when an infectious insult triggers a localized inflammatory reaction that then …

Sepsis represents a dysregulated host response to infection leading to organ dysfunction.
Here, the pathogen triggers an initial exaggerated inflammatory-immune response that leads …

… Many of these cell death pathways are altered during sepsis, either as a direct result of
the pathophysiology of sepsis and associated inflammation or via direct interaction with …

… of sepsis were defined; it was suggested that “Sepsis” would … “Severe Sepsis” would be
defined as sepsis complicated by … and “Septic Shock” would be defined as severe sepsis with …

… sepsis. Many surface receptors expressed on immune cells at various stages of sepsis have
been suggested as biomarkers for sepsis … of immune cells during sepsis, were shown to …

… in sepsis reduce mortality, it is less clear that they prevent or ameliorate sepsis-associated
AKI. This is likely because specific mechanisms underlying AKI attributable to sepsis are not …

Background: Sepsis, a systemic inflammatory response to infection, resulting in organ failure
and death. Pathogenic microbial agents trigger cascades of events in sepsis by stimulating …

… the pathophysiology of sepsis. … sepsis are reviewed, with discussion of scoring systems
used to identify patterns and abnormal vital signs and laboratory values associated with sepsis…

Sepsis is the leading cause of death in critically ill patients in the United States. Yet the … This
review examines evolving concepts of sepsis and discusses new and potential therapies. …