Specific folate receptors are abundantly overexpressed in chronically activated
macrophages and in most cancer cells. Directed folate receptor targeting using liposomes is
usually achieved using folate linked to a phospholipid or cholesterol anchor. This link is
formed using a large spacer like polyethylene glycol. Here, we report an innovative strategy
for targeted liposome delivery that uses a hydrophobic fragment of surfactant protein D
linked to folate. Our proposed spacer is a small 4 amino acid residue linker. The peptide …