Importance Use of next-generation sequencing of RNA and machine learning algorithms
can classify the risk of malignancy in cytologically indeterminate thyroid nodules to limit
unnecessary diagnostic surgery. Objective To measure the performance of a genomic
sequencing classifier for cytologically indeterminate thyroid nodules. Design, Setting, and
Participants A blinded validation study was conducted on a set of cytologically indeterminate
thyroid nodules collected by fine-needle aspiration biopsy between June 2009 and …