Perilipins at a glance

CP Najt, M Devarajan, DG Mashek - Journal of cell science, 2022 - journals.biologists.com
… The perilipins (PLINs) are the most studied and abundant proteins residing on the LD
surface. This Cell Science at a Glance and the accompanying poster summarize our current …

The perilipin family of lipid droplet proteins: Gatekeepers of intracellular lipolysis

C Sztalryd, DL Brasaemle - Biochimica et biophysica acta (bba)-molecular …, 2017 - Elsevier
… At first glance, the phenotype of perilipin 2 null mice appears to be relatively mild, but
significant changes in lipid homeostasis in liver and white adipose tissue are revealed when the …

Perilipins: A family of five fat‐droplet storing proteins that play a significant role in fat homeostasis

P Chandrasekaran, S Weiskirchen… - Journal of Cellular …, 2024 - Wiley Online Library
… Recent evidence suggests that proteins from the perilipin family (PLIN) are associated with
the … Therefore, it is crucial to understand the role of perilipins in this accumulation, as these …

Challenges in pharmacological intervention in perilipins (PLINs) to modulate lipid droplet dynamics in obesity and cancer

V Bombarda-Rocha, D Silva, A Badr-Eddine… - Cancers, 2023 - mdpi.com
perilipins in lipid metabolism and their potential as therapeutic targets for lipid-associated
diseases like cancer and obesity. Perilipins … the primary roles of perilipins, especially in cancer, …

Role of Perilipins in Oxidative Stress—Implications for Cardiovascular Disease

M Cinato, L Andersson, A Miljanovic, M Laudette… - Antioxidants, 2024 - mdpi.com
… In this review, we focus on the role of the LD proteins perilipins (Plins) and their role in
oxidative stress. We will also discuss the implications of Plins and oxidative stress in …

A sideways glance

Y Sambuy - Genes & Nutrition, 2006 - ncbi.nlm.nih.gov
… This issue of Sideways Glance on the role of Perilipin in adipose lipid metabolism coincides
… the association between genetic variations in adipocyte perilipin and the response to dietary …

Parallel CRISPR-Cas9 screens identify mechanisms of PLIN2 and lipid droplet regulation

MA Roberts, KK Deol, AJ Mathiowetz, M Lange… - Developmental Cell, 2023 - cell.com
Despite the key roles of perilipin-2 (PLIN2) in governing lipid droplet (LD) metabolism, the
mechanisms that regulate PLIN2 levels remain incompletely understood. Here, we leverage a …

Binding of perilipin 3 to membranes containing diacylglycerol is mediated by conserved residues within its PAT domain

J Stribny, R Schneiter - Journal of Biological Chemistry, 2023 - ASBMB
Perilipins (PLINs) constitute an evolutionarily conserved family of proteins that specifically
associate with the surface of lipid droplets (LDs). These proteins function in LD biogenesis …

Lipid droplets at a glance

Y Guo, KR Cordes, RV Farese Jr… - Journal of cell …, 2009 - journals.biologists.com
… A, which directly phosphorylates perilipin and hormone-sensitive lipase (HSL). Hormone-stimulated
phosphorylation of perilipin releases CGI-58 from the CGI-58–perilipin complex, …

Effects of perilipin 2 antisense oligonucleotide treatment on hepatic lipid metabolism and gene expression

Y Imai, S Boyle, GM Varela, E Caron… - Physiological …, 2012 - journals.physiology.org
… We previously showed that Perilipin 2 (Plin2), a member of lipid droplet protein family, is
markedly increased in fatty liver, and its reduction in the liver of diet-induced obese mice by …