Perinatal management of a preterm neonate affected by hyperprostaglandin E2 syndrome (HPS)
Background: Neonates affected by hyperprostaglandin E2 syndrome (HPS) present with
severe polyuria. Both urinary losses as well as prostaglandin synthesis inhibitors may
precipitate acute renal failure (ARF). Aim: Our goal was to maintain euvolaemia by
replacement of urinary losses. Patient: Our patient was born prematurely with a family history
typical of HPS. Urinary salt and water losses and PGE2 excretion were determined in 2‐to 4‐
h intervals. Salt and water were replaced accordingly. Results: Within the first 48 h, urinary …
severe polyuria. Both urinary losses as well as prostaglandin synthesis inhibitors may
precipitate acute renal failure (ARF). Aim: Our goal was to maintain euvolaemia by
replacement of urinary losses. Patient: Our patient was born prematurely with a family history
typical of HPS. Urinary salt and water losses and PGE2 excretion were determined in 2‐to 4‐
h intervals. Salt and water were replaced accordingly. Results: Within the first 48 h, urinary …
Abstract
Background: Neonates affected by hyperprostaglandin E2 syndrome (HPS) present with severe polyuria. Both urinary losses as well as prostaglandin synthesis inhibitors may precipitate acute renal failure (ARF). Aim: Our goal was to maintain euvolaemia by replacement of urinary losses. Patient: Our patient was born prematurely with a family history typical of HPS. Urinary salt and water losses and PGE2 excretion were determined in 2‐ to 4‐h intervals. Salt and water were replaced accordingly.
Results: Within the first 48 h, urinary losses and PGE2 increased continuously to 50 ml/kg/h and 374 ng/h/1.73 m2, respectively. Following exposure to 0.05–0.5 mg/kg/d indomethacin, urinary output decreased steadily to 10–15/ ml/kg/h.
Conclusion: In euvolaemic preterm neonates with HPS and the need for excessive replacement of salt and water, inhibition of renal PGE2 excretion with indomethacin effectively reduces polyuria and natriuresis without acutely compromising renal function.
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