Background Excessive repetitive behavior is a debilitating symptom of several
neuropsychiatric disorders. Parvalbumin-positive inhibitory interneurons in the dorsal
striatum have been linked to repetitive behavior, and a sizable portion of these cells are
surrounded by perineuronal nets (PNNs), specialized extracellular matrix structures.
Although PNNs have been associated with plasticity and neuropsychiatric disease, no
previous studies have investigated their involvement in excessive repetitive behavior …