… total knee arthroplasty (TKA), chronic neuropathic pain … perioperative treatment with
pregabalin, a chronic pain medication, would reduce the incidence of postsurgical neuropathic pain…

… One prospective, randomized controlled trial conducted by Jain et al17 was similar to this
study, in that pregabalin was administered in the perioperative period and showed that …

… the effects of preoperative administration of oral pregabalin on postoperative pain control in
… could prevent development of postoperative chronic pain by means of reducing acute brain …

… that the perioperative use of oral pregabalin will reduce … The potential adverse drug
reactions [Table 5], were mostly … of perioperative pregabalin in reducing chronic pain after TKA…

… foreseeable future due to the aging of the population [3]. Postoperative pain after total joint
arthroplasty has … In summary, preoperative administration of pregabalin could improve acute …

… Since, preoperative administration of pregabalin has been found … Future studies could
focus on long-term preoperative … Predictors of persistent pain after total knee arthroplasty: a …

… This prospective, randomized, blinded, placebo-controlled … Pregabalin had no effect on
acute or chronic pain, opioid … perioperative pregabalin for total knee arthroplasty patients. …

… 13 Therefore, lower pregabalin doses should be considered in future studies to minimize
such side effects, hopefully maintaining therapeutic efficacy. One of the limitations of this study …

… Moreover, approximately 10–50% of patients may develop chronic pain after surgery, which
could … , randomized controlled trials with a larger sample size are needed in future work. …

… ; however, TKA has always been associated with a moderate to severe pain after …
Perioperative multiple anaesthesia including oral pregabalin may reduce the pain and reduce the …