Objective: To test the hypothesis that persistent villi hypoperfusion explains intramucosal
acidosis after endotoxemic shock resuscitation. Design: Controlled experimental study.
Setting: University-based research laboratory. Subjects: A total of 14 anesthetized,
mechanically ventilated sheep. Interventions: Sheep were randomly assigned to endotoxin
(n= 7) or control groups (n= 7). The endotoxin group received 5 μg/kg endotoxin, followed by
4 μg· kg− 1· hr− 1 for 150 mins. After 60 mins of shock, hydroxyethylstarch resuscitation was …