Pharmaceutical nanocrystals

GD Wang, FP Mallet, F Ricard, JYY Heng - Current Opinion in Chemical …, 2012 - Elsevier
Development of poorly soluble and/or permeable drug molecules using nanocrystal formulations
has proven to be highly successful due to the greater surface/volume ratio, resulting in …

Drug nanocrystals in the commercial pharmaceutical development process

JP Möschwitzer - International journal of pharmaceutics, 2013 - Elsevier
… by the pharmaceutical industry. In addition, this review will discuss how drug nanocrystals
in general can be successfully used as enabling technology for poorly water-soluble drugs. …

Pharmaceutical nanocrystals: production by wet milling and applications

M Malamatari, KMG Taylor, S Malamataris… - Drug Discovery …, 2018 - Elsevier
… From the different types of nanotherapeutics, we focus here on nanocrystals in the context
of this review. Nanocrystals have a high drug loading (close to 100%) in contrast to matrix NPs …

Nanocrystals technology for pharmaceutical science

Z Cheng, Y Lian, Z Kamal, X Ma, J Chen… - … Pharmaceutical …, 2018 - ingentaconnect.com
… Objective: This review mainly focused on the nanocrystals technology and its application in
pharmaceutical science. Firstly, different preparation methods of nanocrystal technology and …

Recent trends in nanocrystals for pharmaceutical applications

L Sun, Y Hu, L Zhang - Current Pharmaceutical Design, 2018 - ingentaconnect.com
… At the beginning, we introduce the current fabrication technologies for nanocrystalnanocrystal
drugs for pharmaceutical applications are reviewed through the discussion of nanocrystal

Pharmaceutical nanocrystals: A promising approach for improved topical drug delivery

PK Parmar, J Wadhawan, AK Bansal - Drug Discovery Today, 2021 - Elsevier
… approaches and applications of pharmaceutical nanocrystals for topical drug delivery. It also
covers production methods, characterization of topical nanocrystal-based formulations, and …

Pharmaceutical nanocrystals by nanomilling: critical process parameters, particle fracturing and stabilization methods

L Peltonen, J Hirvonen - Journal of pharmacy and …, 2010 - academic.oup.com
… In this review the most important factors affecting nanocrystal formulation and efficacy of
stabilizers are presented. In order to widen understanding of the milling process, the most …

Pharmaceutical strategies for stabilizing drug nanocrystals

H Yang, H Kim, S Jung, H Seo, SK Nida… - … Pharmaceutical …, 2018 - ingentaconnect.com
… drug nanocrystals is their simplicity. Nanocrystals typically contain only pure drugs and do
not require the use of pharmaceutical … For this reason, drug nanocrystal technology has been …

Simple low-cost miniaturization approach for pharmaceutical nanocrystals production

GB Romero, CM Keck, RH Müller - International journal of pharmaceutics, 2016 - Elsevier
… Therefore, a cost-effective miniaturized scale top down approach for nanocrystals production
by wet … scale method for the production of pharmaceutical nanocrystals was established. …

State of the art of pharmaceutical solid forms: from crystal property issues to nanocrystals formulation

BM Couillaud, P Espeau, N Mignet, Y Corvis - ChemMedChem, 2019 - Wiley Online Library
… is to provide a pharmaceutical outlook on … on nanocrystal formulations. This is followed by
a discussion on the advantages and disadvantages of each solid form from a pharmaceutical