Pharmacokinetic–pharmacodynamic target attainment analysis of meropenem in Japanese adult patients
K Ikawa, N Morikawa, K Ikeda, H Ohge, T Sueda… - Journal of infection and …, 2010 - Elsevier
This study was a pharmacokinetic (PK)–pharmacodynamic (PD) target attainment analysis
of meropenem in Japanese adult patients. Plasma drug concentration data (265 samples
from 42 patients) were used for population PK modeling and Monte Carlo simulation to
assess the probability of attaining the PK–PD target (40% of the time above the MIC for the
bacterium). The final population PK model identified creatinine clearance (Cl cr, ml/min) and
body weight (BW, kg) as the most significant covariates: Cl (l/h)= 0.0905× Cl cr+ 2.03, V c (l) …
of meropenem in Japanese adult patients. Plasma drug concentration data (265 samples
from 42 patients) were used for population PK modeling and Monte Carlo simulation to
assess the probability of attaining the PK–PD target (40% of the time above the MIC for the
bacterium). The final population PK model identified creatinine clearance (Cl cr, ml/min) and
body weight (BW, kg) as the most significant covariates: Cl (l/h)= 0.0905× Cl cr+ 2.03, V c (l) …
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