Marble-burying behavior in rodents has been used commonly as an animal model of
compulsive and/or anxiety behavior. The purpose of this study was to further assess the
adequacy of marble burying as a preclinical animal model of compulsive behaviors using
pharmacological tools. In particular, we were interested in whether dopamine D2/D3
agonists (eg pramipexole) known to produce compulsive behaviors in humans would
increase marble burying. The effects of pramipexole on marble-burying behavior and …