Phosphatidic Acid Generation through Interleukin 2 (IL-2)-induced α-Diacylglycerol Kinase Activation Is an Essential Step in IL-2-mediated Lymphocyte Proliferation …
I Flores, T Casaseca, C Martinez-A, H Kanoh… - Journal of Biological …, 1996 - ASBMB
Proliferation of T lymphocytes is triggered by the interaction of interleukin 2 (IL-2) with its
high affinity specific receptor that is expressed on the cell surface following T lymphocyte
activation. Significant advances have recently been made in identifying the multiple signals
that follow IL-2 receptor occupancy, although the exact mechanism responsible for IL-2-
induced proliferation remains an enigma. It has been shown previously that unique species
of phosphatidic acid are rapidly produced in vivo following IL-2 binding. It was then …
high affinity specific receptor that is expressed on the cell surface following T lymphocyte
activation. Significant advances have recently been made in identifying the multiple signals
that follow IL-2 receptor occupancy, although the exact mechanism responsible for IL-2-
induced proliferation remains an enigma. It has been shown previously that unique species
of phosphatidic acid are rapidly produced in vivo following IL-2 binding. It was then …
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