Role of Sb₂O₃ on physical, elastic-mechanical, and gamma-ray protection ability of (70-x)B₂O₃-15CaO-15Li₂O-xSb₂O₃: x = 0, 1, 3, 5, and 8 mol% glass systems was investigated through this report. The density was improved from 2.410 to 2.780 g.cm³ associated with a simultaneous increase in the molar volume from 25.575 to 28.556 cm³/mol as the mol% of Sb increased in the samples. In addition, the oxygen packing density (OPD) and oxygen molar volume (OMV) were decreased and increased, respectively, as a direct response to this increase in Sb mol%. The Gibbs free energy increases from 32.22 to 33.796 kJ/cm³, while Young’s modulus decreases from 43.17 to 41.23 GPa. Therefore, Poisson’s ratio (σ) values were varied from 0.4069 to 0.4153. Vicker’s hardness was improved by enhancing Sb₂O₃ concentration. The observed trend of the mass attenuation coefficient (MAC) parameter was followed as: MAC_Sb0 < MAC _Sb1 < MAC _Sb3 < MAC _Sb5 < MAC _Sb8 with values in the range of 4.176–0.018, 5.907–0.019, 9.032–0.021, 11.775–0.0227, 15.315–0.0245 cm²/g for samples encoded as Sb0-Sb8, respectively.