Pioglitazone reduces cold-induced brown fat glucose uptake despite induction of browning in cultured human adipocytes: a randomised, controlled trial in humans
RKC Loh, MF Formosa, N Eikelis, DA Bertovic… - Diabetologia, 2018 - Springer
Aims/hypothesis Increasing brown adipose tissue (BAT) activity is a possible therapeutic
strategy to increase energy expenditure and glucose and lipid clearance to ameliorate
obesity and associated comorbidities. The thiazolidinedione (TZD) class of glucose-lowering
drugs increase BAT browning in preclinical experimental models but whether these actions
extend to humans in vivo is unknown. The aim of this study was to determine the effect of
pioglitazone treatment on adipocyte browning and adaptive thermogenesis in humans …
strategy to increase energy expenditure and glucose and lipid clearance to ameliorate
obesity and associated comorbidities. The thiazolidinedione (TZD) class of glucose-lowering
drugs increase BAT browning in preclinical experimental models but whether these actions
extend to humans in vivo is unknown. The aim of this study was to determine the effect of
pioglitazone treatment on adipocyte browning and adaptive thermogenesis in humans …
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