The broad and potent activity of piperazine has established it as one of the biologically
important scaffolds. This article is an effort to highlight the importance of the piperazine in the
present context and promise they hold for the future. This review mainly focused the updated
information on the most active piperazine derivatives that have been reported to show
significant biological actions for instance anti-microbial, anti-depressant, anticonvulsant, anti-
parkinson, antiinflammatory, antipsychotic, antioxidant, antidiabetic, antiarrhythmic …