We described recently a subacute serum autoantibody response toward glial fibrillary acidic
protein (GFAP) and its breakdown products 5–10 days after severe traumatic brain injury
(TBI). Here, we expanded our anti-GFAP autoantibody (AutoAb [GFAP]) investigation to the
multicenter observational study Transforming Research and Clinical Knowledge in TBI Pilot
(TRACK-TBI Pilot) to cover the full spectrum of TBI (Glasgow Coma Scale 3–15) by using
acute (< 24 h) plasma samples from 196 patients with acute TBI admitted to three Level I …

Lingsma, Hester; Erasmus MC, Public Health; Yuh, Esther; University of California, San
Francisco, Radiology Mukherjee, Pratik; University of California, San Francisco, Department
of Neurological Surgery; University of California, San Francisco, Radiology Valadka, Alex;
Seton Brain and Spine Institute, Gordon, Wayne; Mount Sinai School of Medicine, Okonkwo,
David; University of Pittsburgh, Dept of Neurological Surgery Manley, Geoffrey; University of
California, San Francisco, Neurological Surgery