Platypus: an open-access software for integrating lymphocyte single-cell immune repertoires with transcriptomes
High-throughput single-cell sequencing (scSeq) technologies are revolutionizing the ability
to molecularly profile B and T lymphocytes by offering the opportunity to simultaneously
obtain information on adaptive immune receptor repertoires (VDJ repertoires) and
transcriptomes. An integrated quantification of immune repertoire parameters, such as
germline gene usage, clonal expansion, somatic hypermutation and transcriptional states
opens up new possibilities for the high-resolution analysis of lymphocytes and the inference …
to molecularly profile B and T lymphocytes by offering the opportunity to simultaneously
obtain information on adaptive immune receptor repertoires (VDJ repertoires) and
transcriptomes. An integrated quantification of immune repertoire parameters, such as
germline gene usage, clonal expansion, somatic hypermutation and transcriptional states
opens up new possibilities for the high-resolution analysis of lymphocytes and the inference …
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