[HTML][HTML] Polymicrobial sepsis and endotoxemia promote microvascular thrombosis via distinct mechanisms
KN Patel, SH Soubra, FW Lam, MA Rodriguez… - Journal of Thrombosis …, 2010 - Elsevier
Background: We reported recently that endotoxemia promotes microvascular thrombosis in
cremaster venules of wild‐type mice, but not in mice deficient in toll‐like receptor 4 (TLR4) or
von Willebrand factor (VWF). Objective: To determine whether the clinically relevant model
of polymicrobial sepsis induced by cecal ligation/perforation (CLP) induces similar
responses via the same mechanisms as endotoxemia. Methods: We used a light/dye‐injury
model of thrombosis in the cremaster microcirculation of wild‐type mice and mice deficient in …
cremaster venules of wild‐type mice, but not in mice deficient in toll‐like receptor 4 (TLR4) or
von Willebrand factor (VWF). Objective: To determine whether the clinically relevant model
of polymicrobial sepsis induced by cecal ligation/perforation (CLP) induces similar
responses via the same mechanisms as endotoxemia. Methods: We used a light/dye‐injury
model of thrombosis in the cremaster microcirculation of wild‐type mice and mice deficient in …
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