Polyunsaturated fatty acids and fatty acid-derived lipid mediators: Recent advances in the understanding of their biosynthesis, structures, and functions
Polyunsaturated fatty acids (PUFAs) are structural components of membrane phospholipids,
and influence cellular function via effects on membrane properties, and also by acting as a
precursor pool for lipid mediators. These lipid mediators are formed via activation of
pathways involving at least one step of dioxygen-dependent oxidation, and are
consequently called oxylipins. Their biosynthesis can be either enzymatically-dependent,
utilising the promiscuous cyclooxygenase, lipoxygenase, or cytochrome P450 mixed …
and influence cellular function via effects on membrane properties, and also by acting as a
precursor pool for lipid mediators. These lipid mediators are formed via activation of
pathways involving at least one step of dioxygen-dependent oxidation, and are
consequently called oxylipins. Their biosynthesis can be either enzymatically-dependent,
utilising the promiscuous cyclooxygenase, lipoxygenase, or cytochrome P450 mixed …
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