Positive and negative regulation of GlnR in validamycin A biosynthesis by binding to different loci in promoter region
S Qu, Q Kang, H Wu, L Wang, L Bai - Applied microbiology and …, 2015 - Springer
Abstract Validamycin A (VAL-A) is a C 7 N aminocyclitol antibiotic produced by
Streptomyces hygroscopicus var. jinggangensis 5008, which has been widely used as
antifungal agent against rice sheath blight disease. VAL-A biosynthesis has been proven to
be affected by γ-butyrolactone and temperature. Herein, we showed that GlnR, a global
regulator in nitrogen metabolism, is specifically associated with valK-valA intergenic
promoter region by DNA-affinity chromatography and MS-based protein identification …
Streptomyces hygroscopicus var. jinggangensis 5008, which has been widely used as
antifungal agent against rice sheath blight disease. VAL-A biosynthesis has been proven to
be affected by γ-butyrolactone and temperature. Herein, we showed that GlnR, a global
regulator in nitrogen metabolism, is specifically associated with valK-valA intergenic
promoter region by DNA-affinity chromatography and MS-based protein identification …
Positive and negative regulation of GlnR in validamycin A biosynthesis by binding to different loci in promoter region.
QS Qu Shuang, KQJ Kang QianJin, WH Wu Hang… - 2015 - cabidigitallibrary.org
Abstract Validamycin A (VAL-A) is a C7N aminocyclitol antibiotic produced by Streptomyces
hygroscopicus var. jinggangensis 5008, which has been widely used as antifungal agent
against rice sheath blight disease. VAL-A biosynthesis has been proven to be affected by γ-
butyrolactone and temperature. Herein, we showed that GlnR, a global regulator in nitrogen
metabolism, is specifically associated with valK-valA intergenic promoter region by DNA-
affinity chromatography and MS-based protein identification. Subsequent EMSA and DNase …
hygroscopicus var. jinggangensis 5008, which has been widely used as antifungal agent
against rice sheath blight disease. VAL-A biosynthesis has been proven to be affected by γ-
butyrolactone and temperature. Herein, we showed that GlnR, a global regulator in nitrogen
metabolism, is specifically associated with valK-valA intergenic promoter region by DNA-
affinity chromatography and MS-based protein identification. Subsequent EMSA and DNase …
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