Possible mechanisms underlying fatty liver in a rat model of male hypogonadism: A protective role for testosterone
Aims: To investigate the effects of testosterone (Test) deficiency and testosterone
replacement therapy (TRT) on the development of non-alcoholic fatty liver disease (NAFLD)
and associated peripheral insulin resistance (IR) in male rats and to illustrate the underlying
mechanisms of action. Materials and methods: male Sprague Dawley rats were divided into
3 groups as follows: 1) sham-operated group (n= 11), 2) ORCD-induced group (n= 9)
exposed to orchidectomy (ORCD), achieved by complete surgical removal of testicles, and …
replacement therapy (TRT) on the development of non-alcoholic fatty liver disease (NAFLD)
and associated peripheral insulin resistance (IR) in male rats and to illustrate the underlying
mechanisms of action. Materials and methods: male Sprague Dawley rats were divided into
3 groups as follows: 1) sham-operated group (n= 11), 2) ORCD-induced group (n= 9)
exposed to orchidectomy (ORCD), achieved by complete surgical removal of testicles, and …
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