Possible role of GABA-B receptor modulation in MPTP induced Parkinson's disease in rats
RK Tyagi, R Bisht, J Pant, ABA Majeed… - Experimental and …, 2015 - Elsevier
Accumulating evidence strongly suggests that gamma amino butyric acid (GABA) receptors
play a crucial role in the pathogenesis of Parkinson's disease (PD). Therefore, the present
study was designed to investigate the role of GABA-B receptor modulation in experimental
models of MPTP-induced PD. MPTP was administered repeatedly on 1st, 7th and 14th day
intranigrally for the induction of PD in Male Wistar rats. Baclofen (10 and 20 mg/kg) and
GABA-B antagonist CGP35348 (10 mg/kg) were given after induction of PD for 14 days …
play a crucial role in the pathogenesis of Parkinson's disease (PD). Therefore, the present
study was designed to investigate the role of GABA-B receptor modulation in experimental
models of MPTP-induced PD. MPTP was administered repeatedly on 1st, 7th and 14th day
intranigrally for the induction of PD in Male Wistar rats. Baclofen (10 and 20 mg/kg) and
GABA-B antagonist CGP35348 (10 mg/kg) were given after induction of PD for 14 days …
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