Background: Sickle cell disease (SS), is one of the most common inherited hematologic
disorders, presents with chronic hemolytic anemia that can be punctuated by crises, infarcts,
organ damage and hypercoagulable state. Sickle cell trait (AS) is a benign disorder.
However, there is an increased risk for several abnormalities such as hematuria and
pulmonary embolism. Coagulation and inflammation cannot be considered as two separate
processes. Protein C is an important link between coagulation and inflammation; activated …