The number of cases of obesity and type 2 diabetes mellitus (T2DM) is part of the metabolic syndrome case. Purslane (Portulaca oleracea L.) is a plant that has been clinically tested and has the potential to prevent and treat metabolic syndrome as well as pathogenic and pathophysiological activities that cause disease. The aim of this study is to discuss and conclude information regarding the activity and use of purslane (P. oleracea) as an antimetabolic. This review article is based on scientific publications found on Google Scholar and PubMed databases using the keywords of “Portulaca obesity”,“Portulaca overweight”,“Portulaca dyslipidemia”, and “Portulaca metabolic syndrome”. This plant acts on numerous pathways in the metabolic syndrome such as reduction of lipids, blood sugar, body weight and total cholesterol. Purslane (P. oleracea) can be used as a candidate for a new herbal plant as an anti-metabolic syndrome.