This paper proposes a fixed switching methodology based on fuzzy sliding mode pulse width modulation (FSMPWM) control strategy for three-phase three-wire unified power quality conditioner (UPQC). The proposed FSMPWM control technique eliminates numerous power quality (PQ) problems such as current harmonics, load unbalance, voltage sag/swell, voltage unbalance, voltage distortion and phase-angle jump existing in the power distribution network. Initially, the design of FSMPWM is based on the implementation of sliding surface by proper extraction of reference current and voltage signals for UPQC. Subsequently, the equivalent control law is formulated for both shunt and series converter. With this consideration, Mamdani fuzzy rule base is designed at the sliding surface for generation of switching pulse. Moreover, the proposed method eliminates the chattering effects by smoothing the control law in a narrow boundary layer for generating fixed switching pulse for both shunt and series converter. The performance of proposed UPQC system has been simulated and analyzed by MATLAB/SIMULINK followed by real-time experimental studies accomplished with a real-time-hardware-in the loop (HIL) system in OPAL-RT simulator. Additionally, the efficacy of this proposed technique is compared with a conventional sliding mode controller (CSMC).