This paper presents an architecture for generalized predictive control for an active prosthetic socket system, based on a cost function performance index measure for minimization of residual limb tissue injury. Finite element analysis of a transtibial residuum model donned with a total surface bearing socket was used to provide controller training data and biomechanical rationale for deep tissue injury risk assessment, by estimating the internal deformation state of the soft tissues and the residuum-socket interface loading under a range of prosthetic loading instances. The results demonstrate the concept of this approach for interface actuation modelled as translational spring and damper systems.