Purpose To provide evidence-based guidance on the optimum prevention and treatment
approaches in the management of chemotherapy-induced peripheral neuropathies (CIPN)
in adult cancer survivors. Methods A systematic literature search identified relevant,
randomized controlled trials (RCTs) for the treatment of CIPN. Primary outcomes included
incidence and severity of neuropathy as measured by neurophysiologic changes, patient-
reported outcomes, and quality of life. Results A total of 48 RCTs met eligibility criteria and …

PURPOSE To update the ASCO guideline on the recommended prevention and treatment
approaches in the management of chemotherapy-induced peripheral neuropathy (CIPN) in
adult cancer survivors. METHODS An Expert Panel conducted targeted systematic literature
reviews to identify new studies. RESULTS The search strategy identified 257 new
references, which led to a full-text review of 87 manuscripts. A total of 3 systematic reviews, 2
with meta-analyses, and 28 primary trials for prevention of CIPN in addition to 14 primary …