Prevention of noise-induced hearing loss with Src-PTK inhibitors
Studies from our lab show that noise exposure initiates cell death by multiple pathways
[Nicotera, TM, Hu, BH, Henderson, D., 2003. The caspase pathway in noise-induced
apoptosis of the chinchilla cochlea. J. Assoc. Res. Otolaryngol. 4, 466–477] therefore,
protection against noise may be most effective with a multifaceted approach. The Src protein
tyrosine kinase (PTK) signaling cascade may be involved in both metabolic and
mechanically induced initiation of apoptosis in sensory cells of the cochlea. The current …
[Nicotera, TM, Hu, BH, Henderson, D., 2003. The caspase pathway in noise-induced
apoptosis of the chinchilla cochlea. J. Assoc. Res. Otolaryngol. 4, 466–477] therefore,
protection against noise may be most effective with a multifaceted approach. The Src protein
tyrosine kinase (PTK) signaling cascade may be involved in both metabolic and
mechanically induced initiation of apoptosis in sensory cells of the cochlea. The current …