Primary association of a TNF gene polymorphism with susceptibility to multiple sclerosis
M Fernandez-Arquero, R Arroyo, A Rubio, C Martin… - Neurology, 1999 - AAN Enterprises
M Fernandez-Arquero, R Arroyo, A Rubio, C Martin, P Vigil, L Conejero, MA Figueredo…
Neurology, 1999•AAN EnterprisesArticle abstract The associations of three promoter polymorphisms in the tumor necrosis
factor (TNFA) gene have been studied in 238 patients and 324 control subjects. A significant
correlation was found between MS susceptibility and the TNFA-376 polymorphism. This
association was independent of the human leukocyte antigen (HLA) class II association and
the combined inheritance of HLA-DRB1* 1501 and the TNFA-376A allele more than
additively increased susceptibility to MS.
factor (TNFA) gene have been studied in 238 patients and 324 control subjects. A significant
correlation was found between MS susceptibility and the TNFA-376 polymorphism. This
association was independent of the human leukocyte antigen (HLA) class II association and
the combined inheritance of HLA-DRB1* 1501 and the TNFA-376A allele more than
additively increased susceptibility to MS.
Article abstract The associations of three promoter polymorphisms in the tumor necrosis factor (TNFA) gene have been studied in 238 patients and 324 control subjects. A significant correlation was found between MS susceptibility and theTNFA-376 polymorphism. This association was independent of the human leukocyte antigen (HLA) class II association and the combined inheritance of HLA-DRB1*1501 and the TNFA-376A allele more than additively increased susceptibility to MS.
American Academy of Neurology以上显示的是最相近的搜索结果。 查看全部搜索结果