For the production of optically active ketoprofen, enzymatic resolution of racemic ketoprofen
in an organic solvent has been accomplished via enantioselective esterification.
Pharmacologically inactive (R)-ketoprofen is converted into the corresponding (R)-ester by
this method. Enantioselectivity in lipase-catalyzed resolution of racemic ketoprofen was
mainly dependent on the sources of lipase, alcohol moiety, organic solvent, and water
content. Ethanol was used as the alkyl donor and the optimum water content required for …