Production of rubusoside from stevioside by using a thermostable lactase from Thermus thermophilus and solubility enhancement of liquiritin and teniposide
TTH Nguyen, SJ Jung, HK Kang, YM Kim… - Enzyme and microbial …, 2014 - Elsevier
Solubility is an important factor for achieving the desired plasma level of drug for
pharmacological response. About 40% of drugs are not soluble in water in practice and
therefore are slowly absorbed, which results in insufficient and uneven bioavailability and GI
toxicity. Rubusoside (Ru) is a sweetener component in herbal tea and was discovered to
enhance the solubility of a number of pharmaceutically and medicinally important
compounds, including anticancer compounds. In this study, thirty-one hydrolyzing enzymes …
pharmacological response. About 40% of drugs are not soluble in water in practice and
therefore are slowly absorbed, which results in insufficient and uneven bioavailability and GI
toxicity. Rubusoside (Ru) is a sweetener component in herbal tea and was discovered to
enhance the solubility of a number of pharmaceutically and medicinally important
compounds, including anticancer compounds. In this study, thirty-one hydrolyzing enzymes …
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