… To determine which brain cell type(s) were overrepresented in the senescent cell … cell
types, as defined in the original studies 19,20 . In cohort 1, excitatory neurons were the only cell …

… profiling of the inflammatory secretome of AD iNs and patient cerebral spinal fluid revealed
a neuronal senescence-… of p16-expressing neurons in AD patient brains, we next sought to …

… of these cells in the brain, their molecular profiles and disease… the senescence process,
revealing that these cells presented … status (S15 Fig) or neuropathological changes (eg, Braak or …

… expression profiles, we assigned clusters to major cell types, … We found little evidence for
drivers of senescence of neurons… Our findings revealed an increase in the expression of the …

… Integrative profiling of the inflammatory secretome of AD iNs and patient … fluid revealed a
neuronal senescence-associated-secretory-phenotype, that can trigger astrogliosis in human …

… neurons of human Alzheimer's disease (AD) brains and during normal aging. Importantly,
selective eliminating p16- expressing cells in AD mouse models attenuates tau … revealed that …

… profiling study also revealed that among the 2% senescent … derived from 76 postmortem
human brains with various levels … excitatory neurons with overlapping neurofibrillary tangle tau …

… (PTMs) in tau obtained from the autopsy of human AD brains revealed that tau can obtain
95 … mice via gene expression profiling of laser capture-microdissected cortical neurons [81]. …

… compared with non-senescent cells in both human patients and mice with atherosclerosis.
Genetic elimination of GPNMB-positive cells reduces the senescent cell burden and alleviates …

… Increasing evidence has revealed that cellular senescence drives NDs, … Neurons with NFTs
have profiles consistent with cellular … plays a critical role in Aβ-mediated neuropathology and …