[HTML][HTML] Proinflammatory cytokines in irritable bowel syndrome: a comparison with inflammatory bowel disease
A Mitselou, V Grammeniatis, A Varouktsi… - Intestinal …, 2020 - synapse.koreamed.org
Intestinal research, 2020•synapse.koreamed.org
Methods IBS and IBD patients along with normal controls were recruited in the study. In all
groups, 2 pinch biopsies were taken at each of 3 anatomical sites (terminal ileum, cecum,
and rectum). IBS patients were also subcategorized according to the syndrome clinical
manifestations. Two monoclonal antibodies (mAb), TNF-α mAb and IL-6 mAb, and one
polyclonal antibody IL-1β mAb were applied for immunohistochemical analysis. Results In
IBD patients intensity of TNF-α and IL-1β were lower than in IBS patients or controls, while IL …
groups, 2 pinch biopsies were taken at each of 3 anatomical sites (terminal ileum, cecum,
and rectum). IBS patients were also subcategorized according to the syndrome clinical
manifestations. Two monoclonal antibodies (mAb), TNF-α mAb and IL-6 mAb, and one
polyclonal antibody IL-1β mAb were applied for immunohistochemical analysis. Results In
IBD patients intensity of TNF-α and IL-1β were lower than in IBS patients or controls, while IL …
Methods
IBS and IBD patients along with normal controls were recruited in the study. In all groups, 2 pinch biopsies were taken at each of 3 anatomical sites (terminal ileum, cecum, and rectum). IBS patients were also subcategorized according to the syndrome clinical manifestations. Two monoclonal antibodies (mAb), TNF-α mAb and IL-6 mAb, and one polyclonal antibody IL-1β mAb were applied for immunohistochemical analysis.
Results
In IBD patients intensity of TNF-α and IL-1β were lower than in IBS patients or controls, while IL-6 was significantly increased comparing to the aforementioned groups. In IBS patients TNF-α was increased comparing to IBD patients or controls, while IL-6 and IL-1β were similar to controls. In IBS subgroups, TNF-α was lower in diarrhea predominant IBS patients and higher constipation predominant IBS patients. Differences among IBS subgroups regarding IL-6 and IL-1β were nonsignificant.
Conclusions
IL-6 seems to be the most important proinflammatory cytokine in IBD patients, while TNF-α could play a more significant role in IBS pathogenesis.
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