The profile of activation of lipid mediator (LM) pathways in asthmatic airway inflammation
remains unclear. This experimental study quantified metabolite levels of ω3-, ω6-and ω9-
derived polyunsaturated fatty acids in bronchoalveolar lavage fluid (BALF) after 4-weeks of
repeated house dust mite (HDM) exposure in a murine (C57BL/6) asthma model. The
challenge induced airway hyperresponsiveness, pulmonary eosinophil infiltration, but with
low and unchanged mast cell numbers. Of the 112 screened LMs, 26 were increased …