… for a variety of transcription factors, but how promoter dynamics affect transcriptional dynamics
has … In this study, we analyze gene models at the transcriptional regulation level, which …

… Therefore, the probability distribution underlying the timing of transcription initiation is
important for understanding cellular dynamics. A distribution where initiations are evenly spaced …

… (A) Transcription dynamics of endogenous and promoter-switched genes. Each panel …
To determine the drivers of transcription dynamics, we used cooccurrence matrices to assess …

… This tight promoter-mediated control of stochasticity may constitute a powerful asset for the
cell. Remarkably, a strongly periodic activity that demonstrates a complex TF concentration-…

… Coupling of transcriptional induction with enhanced mRNA degradation generates a
peaked response that is an important feature of dynamic biological systems that must respond …

… To probe the fundamental dynamic mechanism by which the TA orchestrates transcriptional
… and statistics, we propose the dynamic mechanism for transcriptional initiation. To further …

… Next, we therefore investigated the dynamic promoter responses to varying external
conditions. More specifically, we investigated the dynamic promoter performance with and without …

… distinct role in bursting during transcriptional activation by γ-interferon. The CCAAT element
does not contribute significantly to the constitutive transcriptional dynamics of primary B-cells…

… TSS) on transcription dynamics in vivo. More precisely, we quantified two temporal aspects
of transcription, namely: 1) Synchrony, defined as the degree of inter-nuclear coordination in …

Transcription is regulated through interplay among transcription factors, an RNA polymerase
(RNAP), and a promoter. Even for a simple repressive transcription factor that disturbs …