Both montmorillonite (MMT) and multi-walled carbon nanotubes (MWCNT) are prominent nanofillers incorporated into polymers due to their unique properties. The realization of uniform dispersion of these reinforcing nanomaterials in polymeric matrices without agglomerates remains a key issue in polymer science. In this work, a lyophilized MMT/MWCNT hybrid was incorporated into polylactide (PLA) at varying low mass fractions (0.5, 1.0 and 2.0 wt%). The nanocomposites were prepared by a combined solution/melt blending method. The structure, thermal and mechanical behavior of the obtained nanocomposites were investigated. The morphological and structural studies revealed a strong hybrid-polymer interaction, while the thermal characterization indicated that the hybrid particles synergistically constrain the PLA segmental motions and promote the crystallization of the PLA matrix. The inclusion of the MMT/MWCNT hybrid into the PLA matrix showed an increase in the elastic modulus and tensile strength by more than 45% and 24%, respectively.