Purpose Pancreatic ductal adenocarcinoma (PDAC) is the fourth leading cause of cancer-
related deaths with high recurrence after surgery due to a paucity of effective post-surgical
adjuvant treatments. DC vaccines can activate multiple anti-tumor immune responses but
have not been explored for post-surgery PDAC recurrence. Intraperitoneal (IP) delivery may
allow increased DC vaccine dosage and migration to lymph nodes. Here, we investigated
the role of prophylactic DC vaccination controlling PDAC tumor growth with IP delivery as an …