Hepatic encephalopathy (HE) is a serious neuropsychiatric syndrome due to either acute or
chronic hepatic failure. This study aimed to investigate the possible neuroprotective effect of
chrysin, a natural flavenoid on thioacetamide (TAA)-induced hepatic encephalopathy in rats.
Also the effect of chrysin on motor impairment, cognitive deficits, oxidative stress,
neuroinflammation, apoptosis and histopathological damage was assessed. HE was
induced in Wistar rats by intraperitoneal (ip) injection of TAA (200 mg/kg) for three alternative …