… , misfolded proteins are either degraded or refolded correctly by chaperone proteins that are
involved in protein folding … Indeed, it is now believed that many, if not all, proteins can form …

… fundamentals of proteins; the process of protein folding in the … role of protein folding in
neurodegenerative diseases such as … , is to combat the denaturing effects of these stress-inducing …

… (eg, Alzhemed trial) or serious side effects (eg, the vaccination trial), we believe that prevention
and removal of misfolded aggregates is the most promising strategy to treat ND. It is likely …

… future research in this field will result in exciting new discoveries that might impact other areas
of biology. … of different therapeutic strategies to arrest protein misfolding and aggregation. …

… treatment of neurodegenerative diseases and protein-misfolding ailments The implications of
… These treatment strategies should be directed towards blocking the activity of the causative …

… Protein folding is a tightly regulated process that relies … protein 43 (TDP-43). As a caveat,
we will focus on the wild-type sequence of these proteins, as most neurodegenerative diseases …

… disease, amyotrophic lateral sclerosis and type II diabetes) are characterised by protein
misfolding … the development of therapeutic strategies targeting these diseases. Three promising …

… The accumulation of protease-resistant misfolded and aggregated proteins is a common
mechanism underlying protein misfolding disorders, including neurodegenerative …

… strategies for treatment and diagnosis. In this Review, we provide a critical discussion of the
role of protein misfolding … We will also describe the molecular basis and implications for prion…

… of protein misfolding, aggregation inconsideration of neurodegenerative diseases. The
main … NPs’ effect on protein aggregation in neurodegenerative diseases involving amyloid-beta …