Protein translocation into the ERGIC: an upstream event of secretory autophagy
Macroautophagy/autophagy was recently shown to regulate unconventional protein
secretion through a process called secretory autophagy. How the secretory cargo selectively
enters into the secretory autophagosome has been a central question. Our recent studies
indicate that cargo translocation into the ER-Golgi intermediate compartment, a
compartment contributing membranes to the forming autophagosome, acts as a mechanism
for secretory cargo entry into the vesicle and may be an early step for secretory autophagy.
secretion through a process called secretory autophagy. How the secretory cargo selectively
enters into the secretory autophagosome has been a central question. Our recent studies
indicate that cargo translocation into the ER-Golgi intermediate compartment, a
compartment contributing membranes to the forming autophagosome, acts as a mechanism
for secretory cargo entry into the vesicle and may be an early step for secretory autophagy.
Abstract
Macroautophagy/autophagy was recently shown to regulate unconventional protein secretion through a process called secretory autophagy. How the secretory cargo selectively enters into the secretory autophagosome has been a central question. Our recent studies indicate that cargo translocation into the ER-Golgi intermediate compartment, a compartment contributing membranes to the forming autophagosome, acts as a mechanism for secretory cargo entry into the vesicle and may be an early step for secretory autophagy.
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