Background—Recombinant tissue plasminogen activator (rTPA) is an established treatment
for acute ischemic stroke. The rate and type of protocol violations in rTPA use and their effect
on patient outcomes in this setting are not well understood. Objective—The objective of this
study was to examine associations between protocol violations and outcomes in community-
based rTPA use. Methods—We reviewed medical records of stroke patients treated with
rTPA in 10 acute-care hospitals in Indianapolis from July 1996 to February 1998 and …

Protocol violations in community-based rTPA stroke treatment are associated with
symptomatic intracerebral hemorrhage | CiNii Research … Protocol violations in community-based
rTPA stroke treatment are associated with symptomatic intracerebral hemorrhage … Stroke
32 12-16, 2001 …