… Pulmonary alveolar proteinosis (PAP) is a syndrome defined by progressive accumulation of
surfactant in pulmonary alveoli… risk of secondary infections and/or pulmonary fibrosis 1,2,3 . …

In acquired pulmonary alveolar proteinosis, lipids and proteins accumulate within the
alveoli because alveolar macrophages cannot catabolize surfactants. Surprisingly, alveolar …

… auto-immune, with anti-GM-CSF antibodies blocking activation of alveolar macrophages.
Auto-immune alveolar proteinosis is the most frequent form of PAP, representing 90% of cases. …

… pulmonary lesion. Focal suppurative pulmonary nocardiosis also complicated the proteinosis
in … of the lung, died from progressive pulmonary proteinosis four years after apparent onset, …

… Pulmonary alveolar proteinosis is a rare clinical … the alveolar accumulation of surfactant
components with minimal interstitial inflammation or fibrosis, pulmonary alveolar proteinosis has …

… Pulmonary alveolar proteinosis is a rare but potentially treatable disease, characterized
by impaired surfactant metabolism that leads to accumulation in the alveoli of proteinaceous …

… -rare disease in which the alveolar macrophages are dysfunctional, causing surfactant
proteins (SP) and lipids to accumulate in the pulmonary alveoli, thereby hindering gas exchange.…

… of pathophysiologic mechanisms that impair pulmonary surfactant homeostasis and lung …
paving includes pulmonary edema, pneumonia, alveolar hemorrhage, diffuse alveolar damage, …

… have described the effects of pulmonary lavage on the CT … of patients with pulmonary alveolar
proteinosis that has yet, to … of pulmonary opacities in pulmonary alveolar proteinosis and …

… lipoproteinosis, pulmonary alveolar phospholipoproteinosis) … pulmonary alveoli, with
associated disturbance of pulmonary … Although an effective treatment using pulmonary lavage was …