Pyrrolizidine alkaloids from Echium glomeratum (Boraginaceae)
The methanolic extract of the whole plant of Echium glomeratum Poir.(Boraginaceae) has
afforded five pyrrolizidine alkaloids, three that were (7S, 8R)-petranine (1),(7S, 8S)-
petranine (2), and (7R, 8R)-petranine (3a) or (7R, 8S)-petranine (3b), comprising a tricyclic
pyrrolizidine alkaloids subclass; and two that were known but to the species: 7-
angeloylretronecine (4) and 9-angeloylretronecine (5). All compounds were tested against a
human tumor panel for cytotoxicity; no activity was observed (EC50 values> 20μg/ml).
afforded five pyrrolizidine alkaloids, three that were (7S, 8R)-petranine (1),(7S, 8S)-
petranine (2), and (7R, 8R)-petranine (3a) or (7R, 8S)-petranine (3b), comprising a tricyclic
pyrrolizidine alkaloids subclass; and two that were known but to the species: 7-
angeloylretronecine (4) and 9-angeloylretronecine (5). All compounds were tested against a
human tumor panel for cytotoxicity; no activity was observed (EC50 values> 20μg/ml).
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