The Southern Alps are the retro-vergent belt of the European Alps that developed from Late Cretaceous subduction to Neogene times. The most prominent Alpine thrusts and folds, nowadays sealed off by the Adamello intrusion, were already developed before the continental collision and clasts derived from the eroded pre-collisional wedge can be found in the Cretaceous foredeep sequences. In contrast, the thermal state attained by the Southern Alps during the long-lasting Alpine evolution is still unknown. This contribution provides evidence for Alpine metamorphism in the northern part of the central Southern Alps. Metamorphic conditions are determined for the alkaline Edolo diabase dykes that emplaced in the exhumed Variscan basement rocks before being deformed during the Alpine convergence (D3). The Alpine foliation in the Edolo diabase dykes is marked by actinolite, biotite, chlorite, epidote, albite, and titanite and it developed under greenschist facies conditions at temperature of 350–420 °C and pressure ≤0.2 GPa. The T/depth ratio indicates a minimum of 50–60 °C/km that is compatible with thermal gradients characteristic of arc settings. Based on radiometric ages from the literature, these conditions were attained during the Alpine subduction.