Pattern recognition receptors (PRRs) survey intra-and extracellular spaces for pathogen-
associated molecular patterns (PAMPs) within microbial products of infection. Recognition
and binding to cognate PAMP ligand by specific PRRs initiates signaling cascades that
culminate in a coordinated intracellular innate immune response designed to control
infection. In particular, our immune system has evolved specialized PRRs to discriminate
viral nucleic acid from host. These are critical sensors of viral RNA to trigger innate immunity …