… Here we consider the potential for RNA-guided gene drives … to control the spread of gene
drives and reverse genomic changes. … For example, RNA-guided gene drives could potentially …

… , and constructed a drive capable of overwriting and reversing changes made by a previous
drive. Our results demonstrate that RNA-guided gene drives are capable of efficiently …

… genetic diseases. In this Account, we summarize recent studies that elucidate the biogenesis
of RNA-guided RNA modifications, the roles of RNA modifications in modulating gene …

… Cas9 may enable “RNA-guided gene drives” to edit nearly any gene in sexually reproducing
… These and other RNA-guided gene drives have yet to be demonstrated in the laboratory. …

… the need to improve this aspect when modelling gene drives. … To obtain an overview of
existing gene drive models we … terms “Gene Drive”; “Gene Drives”; Gene-Drive”; “Gene-Drives” …

… Two of us recently used a CRISPR/Cas9-based gene drive … release of flies carrying gene
drive constructs from the laboratory … documented highly efficient RNA-guided gene drive in flies …

… gene drive can be separated into multiple elements. A single drive unit or a “full gene drive”
is when all the drive … When the drive elements are separated into two or more elements it is a …

… A gene drive method of particular interest for population suppression utilizes homing
endonuclease genes (HEGs), wherein a site-specific, nuclease-encoding cassette is copied, in the …

… genomes that direct chromatin modifications and gene expression, synthetic biologists
have repurposed prokaryotic RNA-guided genome defense systems such as CRISPR to edit …

… types of gene drives and the current progress and future considerations concerning their
development, along with novel architectures enabled by RNA-guided endonucleases that may …