RNAi-mediated knockdown of protein kinase C-alpha inhibits cell migration in MM-RU human metastatic melanoma cell line
HR Byers, SJS Boissel, C Tu, HY Park - Melanoma Research, 2010 - journals.lww.com
Protein kinase C (PKC) is a multigene family of serine/threonine protein kinases involved in
cell signaling pathways of proliferation and motility. PKC interacts with Rho GTPases in the
regulation of the actin cytoskeleton. The PKC-α isozyme binds the Rho GTPase cdc42, and
both are coordinated with the Rac-phosphatidylinositol-3 kinase (PI3K) signaling pathway in
melanoma cell invasion and migration on extracellular matrix proteins. To further define the
role of PKC-α in melanoma cell migration, we tested the effect of PDBu and Ca 2+ …
cell signaling pathways of proliferation and motility. PKC interacts with Rho GTPases in the
regulation of the actin cytoskeleton. The PKC-α isozyme binds the Rho GTPase cdc42, and
both are coordinated with the Rac-phosphatidylinositol-3 kinase (PI3K) signaling pathway in
melanoma cell invasion and migration on extracellular matrix proteins. To further define the
role of PKC-α in melanoma cell migration, we tested the effect of PDBu and Ca 2+ …
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