… First, we found that ROCK2 regulates monocytic migration and adhesion toward endothelial
cells, … , it remains unknown how ROCK2 affects other pathological machinery in endothelial …

… found that ROCK2 regulates monocytic migration and adhesion toward endothelial cells, which
… thrombin-induced RelA/p65 nuclear translocation and intercellular adhesion molecule 1 (…

… molecule 1 (VCAM-1) and intercellular adhesion molecule 1 (… diabetes-induced vascular
endothelial dysfunction by … apoptosis and monocyte-endothelial cell adhesion induced …

… platelets could recruit monocytes or induce migration. Initially… located in the intronic region
of ROCK2 on chromosome 2, … -Mac1, which are not completely regulated by ROCK. In our …

… of Rock2 allele (Rock2 +/– ). Although the homozygous … endothelial ROCKs could also affect
monocyte adhesion, the … Male Rock1 +/– , Rock2 +/– , and littermate WT controls were used …

… Moreover, mechanical stress-induced VSMC migration was diminished in VSMCs derived
… monocyte motility, 36 and macrophage from PYK2 null mice showed impaired migration. …

… Subsequently, monocytes that are loaded with cellactivating … vascular endothelium forms the
inner lining of blood vessels … than ROCK2 is up-regulated upon macrophage adhesion [69]. …

… To sum up, our data showed that circCHMP5 regulated the miR-532-5p/ROCK2 axis to …
of vascular endothelial cells leads to the loss of an effective protective barrier of the vascular …

… lipid; monocyte chemotaxis and inflammatory response; leukocyte … hand regulates cell polarity
during endothelial cell migration … A unifying system: does the vascular endothelium have a …

… manner, thereby regulating the time-of-day-variation in ROCK2 activity. … in vascular function
during diabetes (Yao et al., 2013). Studies in macrophages and vascular endothelial cells …