Random forests to predict rectal toxicity following prostate cancer radiation therapy
Purpose To propose a random forest normal tissue complication probability (RF-NTCP)
model to predict late rectal toxicity following prostate cancer radiation therapy, and to
compare its performance to that of classic NTCP models. Methods and Materials Clinical
data and dose-volume histograms (DVH) were collected from 261 patients who received 3-
dimensional conformal radiation therapy for prostate cancer with at least 5 years of follow-
up. The series was split 1000 times into training and validation cohorts. A RF was trained to …
model to predict late rectal toxicity following prostate cancer radiation therapy, and to
compare its performance to that of classic NTCP models. Methods and Materials Clinical
data and dose-volume histograms (DVH) were collected from 261 patients who received 3-
dimensional conformal radiation therapy for prostate cancer with at least 5 years of follow-
up. The series was split 1000 times into training and validation cohorts. A RF was trained to …
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